Obes Surg. 2025 Mar 14. doi: 10.1007/s11695-025-07776-x. Online ahead of print.
ABSTRACT
BACKGROUND: Roux-en-Y gastric bypass (RYGB) is widely regarded as a cornerstone intervention for individuals afflicted with metabolic syndromes and severe obesity. However, one anastomosis gastric bypass (OAGB) emerged after RYGB as a more straightforward and less technically demanding operation. This systematic review and meta-analysis aims to compare both procedures and update the currently existing evidence.
METHODS: We systematically searched PubMed, Scopus, and the Cochrane Central Register for randomized controlled trials (RCTs) that compared OAGB with RYGB as primary operations.
RESULTS: Twelve studies were included in this meta-analysis, with a total of 904 patients. Total weight loss percentage (TWL%) was statistically higher in the OAGB group at 6 months (95% CI 0.80 to 2.94; P = 0.006) with no differences in 12, 24, and 36 months compared to RYGB. On the other hand, OAGB exhibited a significantly higher excess weight loss percentage (EWL%) compared to RYGB at 12 months (95% CI 3.08 to 9.73; P = 0.0002). EWL% was comparable in both procedures at 6, 24, and 60 months of follow-up. There were no statistically significant differences in terms of the resolution of comorbidities related to obesity. De novo gastro-esophageal reflux disease (GERD) (RR 2.58; 95% CI 1.55 to 4.3; P = 0.0003) and marginal ulcers (RR 2.7; 95% CI 1.07 to 6.84; P = 0.04) were significantly higher in patients who underwent OAGB in comparison to RYGB.
CONCLUSIONS: In conclusion, OAGB is comparable to RYGB in terms of weight loss parameters and comorbidity resolution. However, OAGB can lead to a higher risk of development of marginal ulcers and de novo GERD.
PMID:40085185 | DOI:10.1007/s11695-025-07776-x